Meet: WIGS

Although WIGS is a new venture by two male filmmakers, Jon Avnet and Rodrigo Garcia, the focus is on women.  It is an online film organization with content on YouTube, featuring short films and long series with a strong focus on female lead characters.  Many of the noted actresses have starred in big budget films, but also have a healthy independent film career as well:

Virginia Madsen (Sideways, The Number 23, Ghosts of Mississippi)
Dakota Fanning (The Runaways, Coraline, Hounddog)
Jennifer Beals (Lie to Me, The L Word, Roger Dodger)
Maura Tierney (Rescue Me, Diggers, Scotland, Pa.)
Jena Malone (Into the Wild, The Ballad of Jack and Rose, Donnie Darko)
Rosanna Arquette (Silverado, Baby It's You, Desperately Seeking Susan)
Catherine O'Hara (A Mighty Wind, Beetlejuice, Home Alone)